Amin Rostami-Hodjegan,∇, Imran Shah, Martin F. Wilks,§ and Shana J. Sturla*,¶ †Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States ‡University of Konstanz, CAAT-Europe, 78457 Konstanz, Germany

2012-12-13 · Background: Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women. These may alter the exposure to xenobiotics between pregnant and non-pregnant women who receive similar doses, with implications for different susceptibility to environmental pollutants or therapeutic agents.

Translational Modelling in Drug Amin Rostami-Hodjegan Physiologically-based pharmacokinetic (PBPK) models provide a framework for in vitro-in vivo extrapolation of metabolic drug clearance. Many of the concepts in PBPK can have Loop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Amin Rostami-Hodjegan The gut wall consists of many biological elements, including enterocytes. Rapid turnover, a prominent feature of the enterocytes, has generally been ignored in the development Research Explorer. The University of Manchester's research has real-world impact beyond academia.

Univ Manchester, Manchester Pharm Sch, Ctr Appl Pharmacokinet Res, Manchester M13 9PT, Lancs, England.;Certara, Blades in biomedical research, health care and drug development / [ed] Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan, Wien: Springer, 2012, s. Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Sandra Suarez-Sharp, Anders Lindahl, Tycho Heimbach, Amin Rostami-Hodjegan, Michael B Bolger, Siladitya Ray Chaudhuri and Bart Hens. Övriga författare. av S Maharjan · 2015 · Citerat av 3 — Journal of Environmental Science and Health, 28(3), 147-171.

Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation. Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative.

2020年7月17日 Dan Liu,Linzhong Li,Amin Rostami-Hodjegan,Frederic Y Bois,Masoud Jamei. Three global sensitivity analysis (GSA) methods (Morris, Sobol

Köp Biosimulation in Biomedical Research, Health Care and Drug Development av Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan på Bokus.com. Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, practices, and opinions on MIPD while defining an achievable vision for MIPD in clinical care based 2012-12-13 · Background: Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women.

Dr. Amin Rostami-Hodjegan. Manchester, United Kingdom. a.

Article Title: Simulation and prediction of in vivo drug metabolism in human populations from in vitro data Amin Rostami-Hodjegan. University of Sheffield, Sheffield, UK See all articles by this author. Search Google Scholar for this author. First Published November 1, 2006 Rachel H. Rose1, Kevin Feng1, David B. Turner1, Amin Rostami-Hodjegan1,2, Masoud Jamei1 1.
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Amin Rostami-Hodjegan presented new approaches for the investigation of DDIs and showed that PBPK modeling information as part of NDA submissions increased dramatically (12 fold) in the last years. Additionally Mikko Niemi talked about active drug uptake by liver cells and what that means for drug-drug interactions. 2009-01-01 · Review A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of â€˜Bottom-Upâ€™ vs â€˜Top-Downâ€™ Recognition of CovariatesMasoud Jamei, 1 Gemma L Dickinson, 2 Amin Rostami-Hodjegan, 1 3 * [email protected] 1 Simcyp Amin Rostami‐Hodjegan, PhD, PharmD, FCP, Stopford Building, Oxford Road, Manchester, United Kingdom of Great Britain and Northern Ireland, M13 9PT UK. Email: amin.rostami@manchester.ac.uk. Search for more papers by this author Aims Although methadone is widely used to treat opiate dependence, guidelines for its dosage are poorly defined.

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Amin Rostami-Hodjegan presented new approaches for the investigation of DDIs and showed that PBPK modeling information as part of NDA submissions increased dramatically (12 fold) in the last years. Additionally Mikko Niemi talked about active drug uptake by liver cells and what that means for drug-drug interactions.

Review. PubMed PMID: 27506526. 11: Chen R, Rostami-Hodjegan A, Wang H, Berk D, Shi J, Hu P. Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6. Amin is the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester and a Professor of Systems Pharmacology with an active program of training PhD students in various branches of clinical pharmacology Amin Rostami-Hodjegan Hartmut Derendorf (2010 – 2020) Oliver von Richter (2010 – 2018) Amin Rostami-Hodjegan, Professor of Systems Pharmacology, University of Manchester Amin is a Professor of Systems Pharmacology at the Centre for Applied Pharmacokinetic Research (CAPKR) in the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester.

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Thomas M. Polasek, Carl M. J. Kirkpatrick, and Amin Rostami-Hodjegan. Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation.

Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation. Amin Rostami-Hodjegan's 405 research works with 11,975 citations and 7,405 reads, including: Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project 16 Rostami-Hodjegan, A, Amin, AM, Spencer, EP, Lennard, MS, Tucker, GT, Flanagan, RJ. Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients. J Clin Psychopharmacol 2004; 24: 70 –8.